Neuraminidase Inhibitors in Influenza Treatment and Prevention–Is It Time to Call It a Day?
Identifieur interne : 000503 ( Main/Exploration ); précédent : 000502; suivant : 000504Neuraminidase Inhibitors in Influenza Treatment and Prevention–Is It Time to Call It a Day?
Auteurs : César Parra-Rojas ; Van Kinh Nguyen ; Gustavo Hernandez-Mejia ; Esteban A. Hernandez-VargasSource :
- Viruses [ 1999-4915 ] ; 2018.
Descripteurs français
- KwdFr :
- Algorithmes, Antienzymes (administration et posologie), Antienzymes (pharmacologie), Antienzymes (usage thérapeutique), Antiviraux (administration et posologie), Antiviraux (usage thérapeutique), Grippe humaine (), Grippe humaine (traitement médicamenteux), Grippe humaine (épidémiologie), Humains, Logiciel, Modèles théoriques, Oséltamivir (administration et posologie), Oséltamivir (usage thérapeutique), Sialidase (antagonistes et inhibiteurs), Virus de la grippe A (), Virus de la grippe A (enzymologie), Épidémies ().
- MESH :
- administration et posologie : Antienzymes, Antiviraux, Oséltamivir.
- antagonistes et inhibiteurs : Sialidase.
- enzymologie : Virus de la grippe A.
- pharmacologie : Antienzymes.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Antienzymes, Antiviraux, Oséltamivir.
- épidémiologie : Grippe humaine.
- Algorithmes, Grippe humaine, Humains, Logiciel, Modèles théoriques, Virus de la grippe A, Épidémies.
English descriptors
- KwdEn :
- Algorithms, Antiviral Agents (administration & dosage), Antiviral Agents (therapeutic use), Enzyme Inhibitors (administration & dosage), Enzyme Inhibitors (pharmacology), Enzyme Inhibitors (therapeutic use), Epidemics (prevention & control), Humans, Influenza A virus (drug effects), Influenza A virus (enzymology), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Models, Theoretical, Neuraminidase (antagonists & inhibitors), Oseltamivir (administration & dosage), Oseltamivir (therapeutic use), Software.
- MESH :
- chemical , administration & dosage : Antiviral Agents, Enzyme Inhibitors, Oseltamivir.
- chemical , antagonists & inhibitors : Neuraminidase.
- chemical , pharmacology : Enzyme Inhibitors.
- chemical , therapeutic use : Antiviral Agents, Enzyme Inhibitors, Oseltamivir.
- drug effects : Influenza A virus.
- drug therapy : Influenza, Human.
- enzymology : Influenza A virus.
- epidemiology : Influenza, Human.
- prevention & control : Epidemics, Influenza, Human.
- Algorithms, Humans, Models, Theoretical, Software.
Abstract
Stockpiling neuraminidase inhibitors (NAIs) such as oseltamivir and zanamivir is part of a global effort to be prepared for an influenza pandemic. However, the contribution of NAIs for the treatment and prevention of influenza and its complications is largely debatable due to constraints in the ability to control for confounders and to explore unobserved areas of the drug effects. For this study, we used a mathematical model of influenza infection which allowed transparent analyses. The model recreated the oseltamivir effects and indicated that: (i) the efficacy was limited by design, (ii) a 99% efficacy could be achieved by using high drug doses (however, taking high doses of drug 48 h post-infection could only yield a maximum of 1.6-day reduction in the time to symptom alleviation), and (iii) contributions of oseltamivir to epidemic control could be high, but were observed only in fragile settings. In a typical influenza infection, NAIs’ efficacy is inherently not high, and even if their efficacy is improved, the effect can be negligible in practice.
Url:
DOI: 10.3390/v10090454
PubMed: 30149615
PubMed Central: 6163920
Affiliations:
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Le document en format XML
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However, the contribution of NAIs for the treatment and prevention of influenza and its complications is largely debatable due to constraints in the ability to control for confounders and to explore unobserved areas of the drug effects. For this study, we used a mathematical model of influenza infection which allowed transparent analyses. The model recreated the oseltamivir effects and indicated that: (i) the efficacy was limited by design, (ii) a 99% efficacy could be achieved by using high drug doses (however, taking high doses of drug 48 h post-infection could only yield a maximum of 1.6-day reduction in the time to symptom alleviation), and (iii) contributions of oseltamivir to epidemic control could be high, but were observed only in fragile settings. In a typical influenza infection, NAIs’ efficacy is inherently not high, and even if their efficacy is improved, the effect can be negligible in practice.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Moscona, A" uniqKey="Moscona A">A. Moscona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stohr, K" uniqKey="Stohr K">K. Stöhr</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kelly, H" uniqKey="Kelly H">H. Kelly</name></author><author><name sortKey="Cowling, B J" uniqKey="Cowling B">B.J. Cowling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dobson, J" uniqKey="Dobson J">J. Dobson</name></author><author><name sortKey="Whitley, R J" uniqKey="Whitley R">R.J. Whitley</name></author><author><name sortKey="Pocock, S" uniqKey="Pocock S">S. 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Stegun</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hernandez Mejia, Gustavo" sort="Hernandez Mejia, Gustavo" uniqKey="Hernandez Mejia G" first="Gustavo" last="Hernandez-Mejia">Gustavo Hernandez-Mejia</name><name sortKey="Hernandez Vargas, Esteban A" sort="Hernandez Vargas, Esteban A" uniqKey="Hernandez Vargas E" first="Esteban A." last="Hernandez-Vargas">Esteban A. Hernandez-Vargas</name><name sortKey="Nguyen, Van Kinh" sort="Nguyen, Van Kinh" uniqKey="Nguyen V" first="Van Kinh" last="Nguyen">Van Kinh Nguyen</name><name sortKey="Parra Rojas, Cesar" sort="Parra Rojas, Cesar" uniqKey="Parra Rojas C" first="César" last="Parra-Rojas">César Parra-Rojas</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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